Clinical trial weight loss drug
The coprimary end points were the change in body weight and the proportions of patients losing at least 5% and more than 10% of their initial body weight. Recent survey data indicate that 24 percent of U. Appel, M. 0 mg, injected subcutaneously. Article Activity 2005 articles have cited this article Article Elevated blood pressure is a common problem in the United States. H. , Eva Obarzanek, Ph. D. The sponsor, Novo Nordisk, planned and performed the statistical analyses, provided editorial and writing assistance, and provided the trial drugs. P. adults — approximately 43 million people — have hypertension and only 47 percent have optimal blood pressure (systolic blood pressure, 1 Among adults 50 years of age or older, a much higher proportion have hypertension and a much lower proportion have optimal blood pressure. Methods Study Overview We conducted the study from June 1, 2011, through March 18, 2013, at 191 sites in 27 countries in Europe, North America, South America, Asia, Africa, and Australia. Methods We enrolled 459 adults with systolic blood pressures of less than 160 mm Hg and diastolic blood pressures of 80 to 95 mm Hg. For three weeks, the subjects were fed a control diet that was low in fruits, vegetables, and dairy products, with a fat content typical of the average diet in the United States. , M. Efforts to reduce the prevalence of hypertension have focused on nonpharmacologic approaches that lower blood pressure. Table 1 Nutrient Targets, Menu Analyses, and Average Daily Servings of Foods, According to Diet. In this clinical trial, Dietary Approaches to Stop Hypertension, we assessed the effects of dietary patterns on blood pressure. D.
Details of the eligibility and exclusion criteria are provided in the Supplementary Appendix. Conclusions A diet rich in fruits, vegetables, and low-fat dairy foods and with reduced saturated and total fat can substantially lower blood pressure. Media in This Article Figure 1 Mean Systolic and Diastolic Blood Pressures at Base Line and during Each Intervention Week, According to Diet, for 379 Subjects with Complete Sets of Weekly Blood-Pressure Measurements. Key exclusion criteria were type 1 or 2 diabetes, the use of medications that cause clinically significant weight gain or loss, previous bariatric surgery, a history of pancreatitis, a history of major depressive or other severe psychiatric disorders, and a family or personal history of multiple endocrine neoplasia type 2 or familial medullary thyroid carcinoma. Moore, M. Abstract Background It is known that obesity, sodium intake, and alcohol consumption influence blood pressure. Current national guidelines recommend weight control, reduced intake of sodium chloride (salt), reduced alcohol consumption, and possibly increased dietary potassium as nutritional approaches to prevent and treat hypertension. Abstract Background Obesity is a chronic disease with serious health consequences, but weight loss is difficult to maintain through lifestyle intervention alone. Liraglutide, a glucagon-like peptide-1 analogue, has been shown to have potential benefit for weight management at a once-daily dose of 3. Sodium intake and body weight were maintained at constant levels. Media in This Article QUICK TAKE VIDEO SUMMARY The SCALE Trial Figure 1 Liraglutide and Body Weight. D. Figure 2 Liraglutide and Glucose Levels during Oral Glucose-Tolerance Test and Glycemic Status. All the authors were involved in the design or conduct of the study and the preparation of the manuscript, including the decision to submit it for publication, and all attest to the accuracy and completeness of data and the data analyses. This diet offers an additional nutritional approach to preventing and treating hypertension. , Thomas J. , William M. S. Study Design and Treatments Randomization was performed with the use of a telephone or Web-based system provided by the sponsor. Original Article A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure Lawrence J.
